Chelsea boss Antonio Conte has retained the false nine for the game against the Saints.
Alvaro Morata, back from illness that forced the tactical change at Huddersfield, is on the bench, while Eden Hazard players upfront.
Chelsea: Courtois, Alonso, Kante, Hazard, Pedro, Bakayoko, Moses, Willian, Cahill, Christensen, Azpilicueta
Subs: Caballero, Rudiger, Fabregas, Drinkwater, Morata, Zappacosta, Batshuayi
Southampton: Forster, Soares, Yosihda, Stephens, Hoedt, Romeu, Ward-Prowse, Gabbiadini, Bertrand, Redmond, Hojbjerg
Subs: Mccarthy, Davis, Austin, Tadic, Van Dijk, Lemina, Boufal
Referee: Roger East